Which cell type turns into scar tissue during regeneration after injury?

Which cell type turns into scar tissue during regeneration after injury?

• A. Fibroblasts
• B. Keratinocytes
• C. Neurons
• D. Adipocytes

Answer: (A)

Scar tissue after injury is produced by fibroblasts. In wound healing, these cells migrate into the damaged area and synthesize collagen and other components of the extracellular matrix. As they become activated, they can differentiate into myofibroblasts that contract the wound and lay down a dense, collagen-rich matrix, which forms the scar tissue that remains when regeneration is incomplete. Keratinocytes mainly re-epithelialize the surface, neurons regenerate poorly in the CNS and don’t generate scar tissue themselves, and adipocytes store fat rather than repair tissue. So the key cell driving scar formation is the fibroblast.

Scar tissue after injury is produced by fibroblasts. In wound healing, these cells migrate into the damaged area and synthesize collagen and other components of the extracellular matrix. As they become activated, they can differentiate into myofibroblasts that contract the wound and lay down a dense, collagen-rich matrix, which forms the scar tissue that remains when regeneration is incomplete. Keratinocytes mainly re-epithelialize the surface, neurons regenerate poorly in the CNS and don’t generate scar tissue themselves, and adipocytes store fat rather than repair tissue. So the key cell driving scar formation is the fibroblast.